Neuropathy, etc. Velcade (bortezomib) or Bortezomib frequently causes a sensory neuropathy with tingling, numbness, pain or a combination in the feet and hands. Thrombocytopenia or low platelets can occur but resolves easily with stopping the drug as does low white count. Giving it under the skin rather than intravenously lessens many side effects especially neuropathy. Beware also of shingles which Acyclovir may prevent.
Quite a few. 1. Velcade (bortezomib) can affect nerves. It mainly manifests as numbness an pain in hands and feet. Risk increased with prolonged use and when using the drug twice a week. Risk can be decreased by using it subcutaneously (instead of in a vein) and using it once a week. 2. Many patients report diarrhea on velcade (bortezomib). 3. Velcade (bortezomib) can cause blood counts to go down.
Minimal. It us a fairly well tolerated drug. Its main side effect is neuropathy which can menifest as tingling, numbness of the toes and fingers and lead to weakness in the hands if the drug is continued for long time. But it does recover after stopping or change over to once weekly use.