A short answer is 'few to none.
' it may depend on what cream you use, where you use/apply it, how often, and for what purpose. Progesterone
creams used intravaginallyfor women sometimes give mild itching or irritation, the gels also may 'clump' and give discharge. On the skin, irritation sometimes occurs. There are no medically important risks or major side effects to these creams.