What do you suggest if my uncle of age 65 yrs has focus of poorly differentiated squamous cell carcinoma at the base of the tongue he?

Resection. Most squamous Ca's of the tongue are on the lateral anterior 2/3 of tongue. If in the posterior tongue, the approach is by transhyoid pharyngotomy followed by RT and chemo if tumor large. This is especially true if bilateral cervical nodal disease is present.