Will clindamycin lotion help with my acne? And about how long should it take to notice a difference?

May help. Clindamycin, in topical or oral forms, is often used in a treatment regimen for acne. People often see some improvement within a couple of weeks, but often experience a flare after about a month of treatment. After this initial flare, the complexion should remain clear if the treatment is right for you.