is a malignancy of a type of B-lymphocytes, known as a Hodgkin and Reed-Sternberg cell (HRS).
It has been a challenge to study this disease because the HRS cell secretes factors that causes it to be surrounded by large numbers of normal lymphocytes. LRS cell neoplasia appears to result from a combination of gene
mutations, like other lymphomas; and are often infected with EBV
(Epstein Barr virus