Can pernicious anemia or severe vitamin B12 deficiency cause chronic non-specific duodenitis??

Not clear. No clear evidence for the causal-effect relationship between the two. PA is an autoimmue-mediated destruction of parietal cells in stomach, resuling in impairmnent of B12 absorption. Certainly it is possible that pernicious anemia may co-exist or exacerbate duodenitis via immune process or loss of balance in duodenal fluid, or anemia. But the causal-effect relationship is not well established.
Which came first? Pernicious anemia results from the reduced gastric production of intrinsic factor. It is often associated with other autoimmune diagnoses. More commonly duodenitis/gastritis from NSAID overuse of meds like apirin and ibuprofen/Advil and infection with H.pylori causes B12 deficiency. http://emedicine.medscape.com/article/204930-overview#aw2aab6b2b3aa .

Related Questions

Please what's the difference between pernicious anemia and vitamin B12 deficiency. My iron levels are perfect. I'm getting injections for vitamin b12.

Intrinsic factor. Vitamin B12 is present in meat and animal protein foods. Absorption of B12 occurs in the intestine (ileum) and requires intrinsic factor (IF), made by stomach cells. In pernicious anemia, IF production is deficient, and results in anemia, a reduction in hemoglobin/hematocrit. One can be vitamin B12 deficient without becoming anemic and/or without having deficient IF. Best wishes:) Read more...

Hi I have vitamin B12 Deficiency. Doc didn't say pernicious anemia. Everyone said I'm going to get cancers. God im so scared. I've started injections?

B12 def. Are you vegetarian or vegan, they have B12 issues at times because B12 sources are animal. May also be ileitis or intestinal issues where B12 is absorbed ( if not pernicious anemia) or dietary/ age. If you are on injections and you level are adequate ( I like above 400) I would not be concerned ,don't worry. Read more...

I have vitamin B12 Deficiency not pernicious anemia. My doctor told me. My reading was 160. What is that number is it 160mcg.

It's on your report. the lab report should have a reference value. sometimes it is reported as nanograms per milliliter (ng/mL), or as picograms per milliliter (pg/mL) 1 picogram is equal to 0.001 nanograms, making the nanogram a larger unit. when you take b12, the dose is usually in micrograms (mcg) 1 mcg is equal to 1000 nanograms i had to look up all that, by the way. Read more...

My doctor has told me I do not have pernicious anemia. I have vitamin B12 Deficiency. Blood test result was 160. So I have mild vitamin B12 Deficiency?

Get a consult. "Mild vitamin B12 deficiency" is like being "a little bit pregnant." It should not happen -- ESPECIALLY if you are, as you say, pregnant. If this happened because you are a vegetarian, reconsider or start supplementing now. Otherwise, you have a right & duty to know what's happening. Your primary care physician didn't communicate answers to you -- a 2nd physician's input is in order. Read more...

Why we treat megaloblastic anemia caused by vitamin B12 deficiency with folates (folic acid)?

We don't. Megaloblastic anemia caused by B12 deficiency is treated with b12. Folate (folic acid) deficiency also causes meg. Anemia. Some with B12 deficiency are also deficient in b12, but if one has low B12 ; isn't deficient in folate (folic acid) there's no need to supplement with it. But it won't hurt to take folate (folic acid);if you're among the 1/3 of people with problems converting Folic Acid to it's active form you should take l-5-mthf. Read more...

My mom was diagnosed a few years ago with vitamin B12 deficiency/anemia. Could this be a genetic thing?

Not exactly. Pernicious anemia as cause of B12 deficiency is an autoimmune disease. The tendency to develop autoimmune disease is genetic, but not specific for a particular condition. It is not like eye color where you can predict with certainty what will happen. Autoimmune disease is part genetic, but something else has to happen to trigger it. Read more...

Can untreated vitamin B12 Deficiency cause nerve damage? If yes, can it be seen through Nerve conduction study?

Yes and yes. Yes solidly objective B12 deficiency (by formal laboratory test) (usually implying pernicious anemia) can cause nerve damage. Yes, it can be seen on electrodiagnostics except at very early stage. Note that in true B12 deficiency taking oral B12 does not work because the cause is a stomach abnormality that prevents B12 absorption. Solidly objective tests can confirm. Read more...