Number and size
Symptoms of nf1 may be seen at birth and may include light brown sports, six or more measuring 5 mm in greatest diameter in prepubertal individuals and over 15 mm in greatest diameter in postpubertal individuals.
Two or more growths on the iris of the eye
, a tumor of optic nerve, , development of two or more subcut. Nodules, neurofibromas and bone abnormalities of tibia, skull, and spine.