Which controls reflux best: 150mg ranitidine twice a day, 20mg protonix (pantoprazole) twice a day, 40mg protonux once a day or combo of both drugs?

Reflux . A lot of people take protonix (pantoprazole) just once daily at either 20 or 40mg and do well but others, anecdotally, seem to prefer taking the 20 mg dose twice daily. Ranitidine can work well for a lot of people as well (twice daily). however, if your reflux is very severe I recommend that you get an evaluation by a gastroenterologist to make sure it's you're only dealing with simple gastroesophageal reflux.