1 doctor weighed in:

How does cymbalta (duloxetine) work differently from gabapentin for CIPN?

1 doctor weighed in
Dr. Lee Peter Bee
Internal Medicine

In brief: Different mechanism

Chemotherapy-induced peripheral neuropathy (CIPN) are often treated with neuropathic medicine (e.
g. Gabapentin) or selective serotonin and norepinephrine reuptake inhibitor (Cymbalta/Duloxetine). Gabapentin works by mimic GABA receptors (mainly inhibitory receptors) in the synaptic pathway, reduce excitation of neurons. Duloxetine is believe to inhibit pro-inflammatory cytokines in the brain.

In brief: Different mechanism

Chemotherapy-induced peripheral neuropathy (CIPN) are often treated with neuropathic medicine (e.
g. Gabapentin) or selective serotonin and norepinephrine reuptake inhibitor (Cymbalta/Duloxetine). Gabapentin works by mimic GABA receptors (mainly inhibitory receptors) in the synaptic pathway, reduce excitation of neurons. Duloxetine is believe to inhibit pro-inflammatory cytokines in the brain.
Dr. Lee Peter Bee
Dr. Lee Peter Bee
Thank
Get help from a real doctor now
Dr. Vikram Patel
Board Certified,
34 years in practice
976K people helped
Continue
111,000 doctors available
Read more answers from doctors