Do the drugs you take for osteoporosis once a month have less side effects than the daily or weekly pills?

Not necessarily. Oral medication for osteoporosis (bisphosphonates) all have similar side effect profile. Of course, if you take a medicine only once a month vs. once weekly, the frequency or occurrence of side effects will be less. When taking bisphosphonate, important to take with water, stay upright or active afterwards and not lay down, to minimize most common side effect of reflux symptoms.