Can polysorbate 80 in my propafenone HCl cause an irregular heartbeat?

PROBABLY NOT. Polysorbate 80 is ubiquitous in the food/drug industry. It is used as an emulsifier in ice cream. Here, polysorbate makes the ice cream smoother and easier to handle, as well as increasing its resistance to melting. In general, polysorbate 80 is safe and well-tolerated, although a small number of people may be sensitive to this substance and it may be harmful to people with crohn's disease.