Maybe. It has been suggested that lycopene found in tomatoes and in OTC supplements may be beneficial. First thing you should do is have your family physician do a digital rectal prostate exam to make sure your prostate feels normal. Stay away from advertised "medications" that sound too good to be true.
Data seems negative. http://www.ncbi.nlm.nih.gov/pubmed/19370565 and all the other reviews of sal palmetto say the same....doesn't seem to work. In theory the prostate uses a lot of zinc and there is a weak association between zinc, selenium and/or vitamin D deficiency with prostate problems. But not really any data on them. Best data would be fat, dietary, and BEING fat aren't good for you or your prostate.