What is the purpose of monoclonal antibodies?

Diagnosis and Rx. Monoclonal antibodies are used in many diagnostic tests. These are also used in the treatment of some tumors. However, monoclonal immunoglobulins in a person are markers of disease, especially multiple myeloma.

Related Questions

Could you please describe the process of making monoclonal antibodies and what is their purpose?

Hibidoma formation. Technique of Milstein where protein injected in a mouse. Spleen cells removed and B cells separated. The B cell producing antibody A is fused with a malignant antibody, the new cell type having a fused nucleus and producing one antibody. This new cell is immortalized due to the malignant component and is a hybrid cell called a hybridoma producing an antibody from one clone known as a monoclonal. Read more...

What are monoclonal antibodies?

All the same. Antibodies are complex protein molecules made by the immune system. The have a variable portion that can be made specific to a target. "monoclonal" refers to antibodies whose variable regions are all the same. When directed at specific biological targets, e.g. Inflammatory mediators, they can be used as drugs ("biologics") to modify diseases. Read more...
Specific antibodies. Monoclonal antibodies are monospecific antibodies that are the same because they are made by identical immune cells that are all clones of a unique parent cell, in contrast to polyclonal antibodies which are made from several different immune cells. Monoclonal antibodies have monovalent affinity, in that they bind to the same epitope. Read more...

What are these monoclonal antibodies?

Abs from one cell. Monoclonal antibodies are those that are produced by the identical immune cells that are descended from the same parent cell. They produce anitibodies that bind to only one epitope or site on an antigen. This means that they are monospecific. This makes them useful in things like research because they can isolate a strain purely and completely. Read more...

Does the presnce of monoclonal antibodies indcate abnormal condition?

Yes. Monoclonal antibodies are important as medications and diagnostic tools, but if you are making a very large amount of one antibody, it's concerning for plasma cell myeloma. A small spike without other signs of trouble is "monoclonal gammopathy of uncertain significance" and is a small risk for trouble in years or decades. Find out what's up & i wish you luck. Read more...

What are the advantages of monoclonal antibodies over normal antiserum?

Specific. Antiserum represents a polyclonal mixture of antibodies that frequently are not tolerated when needed and do not have the same therapeutic effect as a dose of a monoclonal given at 3-4mg./kg. A monoclonal antibody, is a pure antibody obtained from immunized B cells fused with a myeloma cell to give it immortality ( a hybrid Ca or oma cell). It is frequently produced in humanized form. Read more...

What are the advantages monoclonal antibodies offer over normal antisera?

More effective. Before Milstein developed the concept of monoclonal antibodies derived from a fused B cell with myeloma cell (hybidoma) all antibodies were polyclonal. They were derived from injecting protein into a horse or cow and extracting the serum which contained antibodies against foreign organisms, and food products. Activity was poor. Monoclonals are now genetically engineered as human and functional. Read more...

Hello. I need some information about the drugs that are monoclonal antibodies and their mechanisms..

Omalizumab - asthma. Good afternoon, omalizumab is a humanized igg1 antibody we use to treat patients with difficult asthma. This antibody blocks ige, which triggers production of sequences of chemical that result in symptoms of allergy. Monoclonal antibodies which are cloned antibodies, are directed against antigens, substances that stimulate an immune reaction. In asthma, it competes with ige and blocks them. Read more...

Would you get cancer from monoclonal antibodies?

No. Monoclonals antibodies are forms of gamma globulin made by a cell type noted as hybridoma which is a fused benign B cell with a malignant B cell, producing one clone of antibody in perpetuity The gamma globulins if specific for a known tumor protein, hunt see and destroy the tumor by a mechanism known as ADCC and do not accomplish the reverse, that is induce malignancy. Read more...