6 doctors weighed in:

Why does doxorubicin (cancer drug) have a greater effect on heart?

6 doctors weighed in
4 doctors agree

In brief: Myocyte damage

Adriamycin ( doxorubicin ) originally derived from bacteria, an antibiotic used in cancer treatment can damage cardiac myocytes by interfering oxygen transport inside the cell , (by decreasing in mitochondrial oxidative phasphorylation ), by simple words choking heart muscle cells.
It is dose related..

In brief: Myocyte damage

Adriamycin ( doxorubicin ) originally derived from bacteria, an antibiotic used in cancer treatment can damage cardiac myocytes by interfering oxygen transport inside the cell , (by decreasing in mitochondrial oxidative phasphorylation ), by simple words choking heart muscle cells.
It is dose related..
Dr. Addagada Rao
Dr. Addagada Rao
Thank
Dr. Andrew Turrisi
Radiation Oncology
2 doctors agree

In brief: All drugs are

Poisons, the anthracycline class tends to cause cumulative, permanent myocardial damage leading to cardiomyopathy if the maximal dose is exceeded.
It also injures the marrow. It does not hurt the liver that excretes its byproducts, or the kidneys or lungs. Each anti-cancer drug has a "dose limiting toxicity".

In brief: All drugs are

Poisons, the anthracycline class tends to cause cumulative, permanent myocardial damage leading to cardiomyopathy if the maximal dose is exceeded.
It also injures the marrow. It does not hurt the liver that excretes its byproducts, or the kidneys or lungs. Each anti-cancer drug has a "dose limiting toxicity".
Dr. Andrew Turrisi
Dr. Andrew Turrisi
Thank
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