Related Questions

My grandfather 94yrs old having prostate cancer and also has metastasis in pancrease (pancrelipase) and bones. Treatment options?

No treatment. In spite of your grandfathers clinical condition, the pattern of behavior of prostate cancer after 80 , for the most part typified by an indolent form of metastasis. One uses drugs like Lupron (leuprolide) to reduce hormones but at his age there are probably little or no hormones secreted. Chemo such as Taxol not utilized. Therefore he should live normal expected time for a 90yo without further intervention. Read more...

My dad is 68 years old. Recently, he was dignosed with advanced prostate cancer with skeletal bone metastasis. What kind of hormone therapy shall he use? Is orchiectomy ok?

Yes. Orchiectomy is nearly instantly effective in reducing testosterone levels and can be done as an outpatient. Alternatives include injections (lhrh agonists) to reduce testosterone levels. These are relatively expensive over the long term, but preserve the testicles which is why many men prefer this option. Surgery is permanent whereas shots can be withheld, but permanent may be best with bone mets. Read more...
Disagree... As mentioned orchiectomy is permanent. There are other chemical options, including estrogen therapy as well as drugs which de-stimulate the pituitary from making lh and fsh. No direct proof confirms that testosterone per se is a cause. It may more be 5-dht. Men who lack 5-a-reductase do not get bald or prostate ca. Therefore drugs that block conversion to 5-dht may be used in tandem. Read more...
D/W your oncologist. Many options available for metastatic prostate ca- medical and surgical therapy. Orchiectomy can be done and will be for sure decrease testosterone permanently. Anti androgen tx like- Lupron (leuprolide) injection, oral casodex- or the newer oral agents that are more sensitive like x-tandi , abiraterone- are available. Not too forget- vaccine & chemo are available as well.Pls d/w oncologist in detail. Read more...
Orchiectomy OK but. The standard of care is an lhrh agonist (such as lupron, zoladex) injection combined with a drug taken by mouth called casodex. The Casodex should be used for a minimum of 1 month and then can be stopped. The advantage is that these injections can be as little as once every 6 months. Alternatively, a drug called Firmagon (degarelix) (an lhrh antagonist) can be given monthly without the casodex. Read more...

Dad has advanced prostate cancer with bone metastasis. After orchirectomy, psa down from 270 to 10. Shall he start zometa or xgeva (denosumab)? Which is better?

See Below. Use of bisphosphanates for your dad can be controversial. Here is an excerpt from a recent review article on www.cancernetwork.com which you can use to discuss with your father's doctor to decide what is best for your dad. http://www.cancernetwork.com/bone-metastases/content/article/10165/105118. Read more...
Either . Xgeva (denosumab) does have some advantages over zometa: quicker administration and no kidney side effects. It is associated with fewer bone complications from cancer than zometa. On the other hand, zometa is now generic, meaning that is a lot cheaper. Neither is a curative treatment for prostate cancer and they are both considered adjunct treatments. Thes small differences may or may not justify its use. Read more...
Off label. Neither zoledronate nor Denosumab is approved for disease that has not progressed on initial hormonal therapy. I would recommend waiting until disease progression and thus avoid potential side effects from these treatments. Read more...