What are the side effects when using serms or ais?

Several. All of these drugs effect hormone balance so that menopausal complaints top the list such as hot flashes, weight gain etc. Muscle cramps, vaginal discharge, are more likely with serms. In premenopausal women irregular periods or loss of periods is likely. Blood clots and uterine cancers are rare problems with serms and not ai bone aches, joint pain, and bone loss are more common with ai.