2 doctors weighed in:

With motor neuron disease would the muscle weekness come before the painless muscle twitching when at rest?

2 doctors weighed in
Dr. Forshing Lui
Neurology
1 doctor agrees

In brief: Motor neuron disease

There are two types of neuronal loss in motor neuron disease.
Upper motor neuron problem causes weakness without fasciculations (muscle twitch). Lower motor neuron involvement may present with fasciculations before any noticeable weaknees. Therefore weakness may come before, during or after the onset of fasciculations. You need to see a neurologist rather than worrying about the disease.

In brief: Motor neuron disease

There are two types of neuronal loss in motor neuron disease.
Upper motor neuron problem causes weakness without fasciculations (muscle twitch). Lower motor neuron involvement may present with fasciculations before any noticeable weaknees. Therefore weakness may come before, during or after the onset of fasciculations. You need to see a neurologist rather than worrying about the disease.
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