5 doctors weighed in:
Why tyramine is contraindicated with mao inhibitor?
5 doctors weighed in

Dr. Michael Sinclair
Family Medicine
4 doctors agree
In brief: Increase BP
Tyramine in large doses can raise your blood pressure, that can cause a stroke and death.
Small doses don't do that because there is enough MAO in your intestinal tract to metabolize the tyramine. When you take a MAO inhibitor, tyramine is no longer metabolized in the gut, so it is free to raise your blood pressure to a very high level. This is less likely to happen with topical MAO called emsam.

In brief: Increase BP
Tyramine in large doses can raise your blood pressure, that can cause a stroke and death.
Small doses don't do that because there is enough MAO in your intestinal tract to metabolize the tyramine. When you take a MAO inhibitor, tyramine is no longer metabolized in the gut, so it is free to raise your blood pressure to a very high level. This is less likely to happen with topical MAO called emsam.
Dr. Michael Sinclair
Dr. Michael Sinclair
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1 comment
Dr. Pamela Pappas
If using the 20mg/20cm patch (delivering 6mg deprenyl/24 hours, one may not have the typical dangers of tyramine-induced hypertensive crisis -- but at higher doses, the dietary restrictions do need to be followed. Some depressed patients need these higher dose patches.
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