Can Buspar (buspirone) worsen clinical depression, left untreated, for the way it works with serotonin and dopamine?

No, buspar (buspirone) doesn't . Commonly effect mood. To the extent that one ignores treatment because they're feeling well, it is on only a matter of time until they will, unfortunately , feel worse (relapse). It does sound like you drink quite a bit, and this can also affect mood very negatively. If you feel suicidal, make sure to ring your doc *right now* and head to ur closest ER or call 911 and have ur MD paged from ER.