Can the destruction of neurons nerve cells body cause chaos in the brain and body and affect chemical and electrical signals in the body?

Sometimes Yes. This question is vague and unclear, but with that said I can acknowledge that brain and body are electrical energy systems connected by miles of nerve fibers. There is much yet to be understood about the brain, but enough is known about spinal cord and brain dysfunction to know that a significant enough insult or damage to any one area can disrupt various other system processes. .