3 doctors weighed in:
Can one's body develop a resistance to Benadryl (diphenhydramine) if one takes it on a daily basis? Will the medicine eventually lose it's effectiveness as time passes?
3 doctors weighed in

Dr. Robert Greer
Family Medicine
2 doctors agree
In brief: Yes
All antihistamines can lose effectiveness.
Most are over the counter now and i'd recommend switching to another family like allegra, claritin, (loratadine) or tavist.

In brief: Yes
All antihistamines can lose effectiveness.
Most are over the counter now and i'd recommend switching to another family like allegra, claritin, (loratadine) or tavist.
Dr. Robert Greer
Dr. Robert Greer
Thank
Get help from a real doctor now
Dr. Christopher Crosby
Board Certified, Dermatology
12 years in practice
93K people helped
Continue
107,000 doctors available
Read more answers from doctors