DNA mutations. Leukemias occur due to mutations in dna. Many mutations have been linked to aml, however, the cause for most of the mutations remains unclear. Known risks include radiation exposure and certain chemical exposure.
Hard to say... Many times we don't know what causes leukemia, irrespective of type. The process is probably multifactorial and has a strong genetic component. In a small subset of cases exposure to various toxins like paint fumes, or to radiation, can also cause it, but this represents only a small percentage of patients.
Is it possible for brief but direct exposure to toxic pest-control chemicals cause acute myelogenous leukemia?
Not likely. If chemical exposure is responsible for leukemia or other cancers it is prolonged exposure that is felt to be necessary.
AML. This is a type of leukemia. It is a cancer of a certain blood dell, originating in the bone marrow. It causes low blood counts. Diagnosis is often by evaluation of bone marrow aspirate. Treatments depend on subtypes and range from standard chemotherapy to bone marrow transplant.
Possibly. If the leukemia develops out of a myelodysplasia and has evidence of a 5q-, then possibly. But, the results are mediocre at best. Not curative by any stretch but could possibly slow the leukemia down for a short time. Hope this helps.
It depends. There are a variety of different subtypes of aml. See this link for further details. Http://www. Cancer. Gov/cancertopics/pdq/treatment/adultaml/patient/page1.
Chloroma is.... A solid leukemia mass, also known as a granulocytic sarcoma, that is traditionally associated with aml. Indeed, chloromas are often associated with specific subtypes of aml, such as those that have the t (8;21) translocation. Treatment for them is the chemotherapy for the disease, although radiation therapy is sometimes used if the chloroma places adjacent structures at risk. Talk with your doctor.
Possibly. We do use it if they have chromosomal changes that predict response. However, not the standard of care. Mainly used if the person is not in the best of shape and looking for alternative, non aggressive options. Hope this helps.
Hmmmm.... While abdominal pain can be seen in patients with AML at diagnosis, for example from splenic infiltration by leukemia cells, bleeding or clotting episodes, etc., this is far from the first (or even 10th) thing that I think of in a patient with abdominal pain. I'm wondering why you are making this connection. Sounds like you need to have a frank conversation about this concern with your dr.
Translocation. A big word but dna is always recombining when cells divide. In this case, a piece of dna from chromosome 9 moves over to chromosome 22 which essentially turns on a switch that produces an enzyme that promotes uncontrolled cell division and leukemia. Modern drugs are targeted to prevent the action of this enzyme.
See below. CML is a type of leukemia caused by a genetic abnormalty, namely a translocation between chromosomes 9 and 22 resulting in the philadelphia chromosome. This leads to a fusion of two genes, bcr ; abl, and the fusion product stimulates the proliferation of myeloid cells uncontrolably. However, the exact cause of the translocation itself is uncertain.
Infiltration. The speen does enlarge in this disease. The causes include direct inflitration. Another is production of other blood elements (extramedullary hematopoesis) in the speen in response to either replacement of the marrow with CML or scar. The scarring is called myelofibrosis.
A blood cancer. CML is a blood cancer that develops slowly (hence chronic). If untreated it will eventually be life threatening. It is associated a unique chromosomal injury, the philadelphia chromosome. New drugs (tkis) target this damage and reliably produce remissions in early stage patients that often are long lasting.
See below... Chronic myelogenous leukemia (CML) is a type of leukemia, which is a type of blood cancer. Like other chronic leukemias, CML is not particularly aggressive and can be successfully treated in most patients.