Possibly. If Fuzeon (enfuvirtide) is not combined with 2 other drugs that also have activity against that person's hiv, resistance quickly develops and it stops working. So a new regimen needs to be carefully constructed using information on prior medications and HIV genotypes. It is an injection twice a day so people need to decide if this is right for them. Fuzeon (enfuvirtide) can be an important part of a new suppressive regimen.