1 doctor weighed in:

Do chlortrimeton's effects last as long as benadryl's?

1 doctor weighed in
Dr. Thomas Seck
Pediatrics

In brief: Much longer

Benadryl (diphenhydramine) leaves the system about twice as fast.
It's half-life (time for 1/2 of it to leave the body) is 3.4 to 9.2 hours. Chlor-trimeton (chlorpheniramine)'s half-life is 20-24 hrs for adults and 10-13 hrs in children. That means Benadryl is 75% gone in 7-18h rs and chlor-trimeton's still going strong after 40-48 hrs (in adults).

In brief: Much longer

Benadryl (diphenhydramine) leaves the system about twice as fast.
It's half-life (time for 1/2 of it to leave the body) is 3.4 to 9.2 hours. Chlor-trimeton (chlorpheniramine)'s half-life is 20-24 hrs for adults and 10-13 hrs in children. That means Benadryl is 75% gone in 7-18h rs and chlor-trimeton's still going strong after 40-48 hrs (in adults).
Dr. Thomas Seck
Dr. Thomas Seck
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