Can I take pain killers for a headache if I just took my Wellbutrin (bupropion) and Prozac doses an hour ago? Or should I wait?

Yes, you can. After neuroimaging and physical examination have excluded structural damage of the brain, headache management depends upon the particular type of headache that is present. Then you can take your pain killer immediately to break the headache ASAP. See your PCP for more information.