How long does Ultram last for pain? Vicodin is stronger but doesn't seem to work as well or last as long. Is Ultram safer

6-8 hours. Half of the medicine is gone from your body in 6-8 hours. Medication is generally prescribed every 6 hours. Vicodin is stronger and half of the medication is gone in 3-5 hours. Historically tramadol has been considered safer. There is some controversy right now on it's safety, but it has been out for 15 years already. In general 325 or less acetaminophen on hydrocodone tabs are preferable.