I take Zoloft (sertraline) 25mg in the morning. Is it OK to take NightRest™ With Melatonin at night?

Yes. Nightrest is GABA, short for Gaba-aminobutyric acid which is an inhibitory neurotransmitter with Melatonin. If you are on the right dose of Zoloft (sertraline), (sertraline) you may not need to take a sleeping medication. The Zoloft (sertraline) may also cause daytime sedation so it might be to take it after supper.