Prednisolone controls lupus but side effects destroying her skin elasticity causing deep depression. Sos!?
Corticosteroids! Prednisone and related drugs increase Insulin resistance, depress growth hormone secretion, thin the skin, cause personality changes, etc. These are proportional to dose. These are quite common. I believe in low doses for most people who may benefit from them. Of all the drugs I use, corticosteroids are the most universal in side effects.