Lupron (leuprolide) shot and side effects?

Hot Flashes. By far, the most common side effect is hot flashes, because Lupron (leuprolide) causes a temporary menopause. Poor sleep resulting in emotional side effects or head ache are also common. A serious effect from long-term Lupron (leuprolide) is osteoporosis. Many of these side effects are reduced or eliminated with extra "add-back" hormones. Some women have no side effects at all.