Yes. Like ERT. The increase risk is similar to that of unopposed estrogen replacement therapy. It is important that all your doctors (esp your gyn in this case) are aware what medications you're taking and report any irregular vaginal bleeding/discharge or other pelvic symptoms.
Yes. Studies have shown that women taking tamoxifen have twice the risk of developing uterine cancer as compared to the general population. However, the benefits of tamoxifen far outweigh this risk when treating many breast cancers. When taking tamoxifen, it is critical to see your gynecologist yearly and be mindful of any pelvic pain or irregular menstrual bleeding.
How high are my risk of endometrial cancer. I am a breast cancer survivor of 6 yrs. Am on tamoxifen. My sister was diagnosed with endometrial cancer,?
Very low. Endometrial cancer is rarely hereditary, so it is highly unlikely that you will have this problem due to the fact that your sister had it. Breast cancer is not associated with it either. Tamoxifen usage has some small increased risk for endometrial but it can be easily monitored with once yearly Ultrasound test of your uterus. Do tell us know if you have any problems.
3 years ago I had breast cancer. Had chemotherapy was put on tamoxifen then letrozole, now have complex cyst on uterus. How likely is this to be cancer?
Biopsy. Only a biopsy can give a confirmation whether it is benign or cancer. Good luck!
Unlikely. Unlikely related to tamoxifen but it still needs to be evaluated. Hope this helps.
Yes. Tamoxifen can stimulate the utermine lining, can cause abnormal menstrual type bleeding, and could be a risk factor for uternine cancer. The benefits far outweight the risks, though. Tamoxifen can also increase the risk of blood clots, but lowers osteoporosis risk.
Yes, it does. Yes! Tamoxifen is a quirky drug! It binds to the estrogen receptor on cells, and in most places blocks the activity of estrogen. But in some places, including the uterus, tamoxifen turns on the receptor instead of turning it off. This causes the lining of the uterus to build up and get thick. This slightly increases the risk of uterine cancer, especially in older women.
Yes. Tamoxifen has been shown to increase the risk of uterine cancer, not unlike estrogen replacement therapy, with an incidence of ~1:500. However, this is almost-always caught at its earliest stage, with very high cure rates. If you compare the benefit of tamoxifen for either treating or preventing breast cancer compared to this risk, the benefit far outweighs the risk.
Tamoxifen. If you get vaginal bleeding, you need a biopsy of the endometrium. Some doctors do ultrasounds looking for polips as well.
Maybe. There is a slight increased risk of endometrial cancer of 1 in 500 chance reported. The benefits of tamoxifen in treatment of breast cancer is much higher than the risk of endometrial cancer. Ask your oncologist and ob-gyn how best to follow or watch for this potential risk.
It can. Studies show that women who take tamoxifen have twice the risk of uterine cancer as compared to non treated patients. However, the benefits of tamoxifen for the treatment of breast cancer far outweigh the risks. Aromatase inhibitors are a group of drugs that can be used instead of tamoxifen for post-menopausal breast cancer patients; these drugs do not have this risk.
Yes. The chance is about 1% and treatment is hysterectomy. With such a low chance then tamoxifen is worth the risk. A gynecologist needs to keep track of the patient and any unusual bleeding evaluated. There are also other hormone alternatives with less risk. Check with your medical oncologist to see which drug is best for a particular patient.
Breast cancer and uterine cancer in my family. I have back/leg with ovarian volume at 49ml, 19mmthicken endomet wall. Constipation and pelvic pain?
Get tested. I can't tell you what your doctor should do, but I would be aggressive with you. You didn't give enough info to say much. How old are you? You have a family history of breast &/or ovarian cancer: who are they? One side of the family or both. Have you had genetic testing? Talk to your doctor about these issues.
Pelvic pain. There are many causes of pelvic pain and constipation. Pain in the pelvis does not point to a specific cause. If it is persistent, see your doctor.
Hormone replacement therapy. Estrogen alone increases risk of uterine cancer. Adding progesterone increases risk of breast cancer, but reduces risk of uterine cancer. What's the right balance?
Individual. Yes, estrogen alone does increase the risk of uterine cancer over time. And yes the whi showed that the combination of a certain synthetic estrogen and a certain synthetic progestin increased the risk of breast cancer. But most specialists do not use those older types of synthetic hormones and with newer medications the risks are lower and different. So a balance can be achieved.