How safe is it to take vistaril (hydroxyzine) while you drink?

Additive effect. Vistaril (hydroxyzine) is an antihistamine also used for anxiety and insomnia; so it can cause sedation. Alcohol (ethanol), being a depressant can further sedate & impair psychmotor function. Best to avoid the combination, especially if driving or operating machinery or if you intend to drink several drinks.