How do you get rid of the horrible pain in your legs after solu-medrol?

Not Related. A single IV dose of solumedrol (methylprednisolone) should not cause pain in the legs of a healthy individual. It may temporarily exacerbate, the pain of peripheral neuropathy on a diabetic patient. Patients with ms have reported such events, but again, it is an exacerbation of a pre-existing condition and treatment is prescribed accordingly.