Could smoking cigarettes really effect xanax (alprazolam)?

Not technically. Nicotine is a stimulant which can cause agitation which can negate the anti-anxiety effects of xanax (alprazolam). There are no significant drug-drug interactions.
Nicotine. No drug interactions are reported between nicotine and Xanax. However, nicotine wears off and can make you feel more stressed, jittery, and anxious making you want to take more Xanax.