Whats a monoclonal antibody?

Antibody to one site. Monoclonal antibodies (mab or moab) are monospecific antibodies that are the same because they are made by identical immune cells that are all clones of a special parent cell. Monoclonal antibodies have monovalent affinity. That is, they bind to the same epitope/site. These can be used in treating cancer, autoimmune diseases, like rheumatoid arthritis, and in diagnostic tests, like western blot.

Related Questions

Discuss monoclonal antibody production?

Monospecific Ab. Monoclonal antibodies are those that are produced by the identical immune cells that are descended from the same parent cell. They produce anitibodies that bind to only one epitope or site on an antigen. This means that they are monospecific. This makes them useful in things like research because they can isolate a strain purely and completely. Read more...

Hello. What is the monoclonal antibody? How it works?

There are many. Before hybridoma technology, if we wanted an antibody against something, we had to inject an animal and get a diverse mixture. Today, a single antibody with a specific sequence can be produced in unlimited quantities. It was one of the key breakthroughs in 20th century medicine & a many diagnostic & therapeutic agents resulted. Read more...
Monoclonal antibody. A monoclonal antibody means that it is a specific antibody made by a cell, and that all the antibodies are the same. Usually this is done to try to target a specific receptor on a cell or virus. For instance if a scientist finds a susceptible part of a virus and wants to target it, they will try to create an monoclonal antibody to bind to it. This process is done for a multitude of reasons. Read more...

Describe polyclonal and monoclonal antibody production?

Cells vs, animals. A monoclonal antibody is produced by in-vitro manipulation by expoanding a single cell making a desired antibody. Polyclonal antibodies are usually derived from immunizing an animal and colletcting its blood/serum containing the antibody. Polyclonal antibodies are a mixture of a large number of different cells. Read more...

What is the definition or description of: monoclonal antibody?

Antibody to 1 target. Antibodies are proteins made by the immune system to block or neutralize foreign substances in the body. Monoclonal antibodies are artifical antibodies created in the lab to block or neutralize a specific target. They are produced from a single cell (i.e., single clone) and thus only bind to one specific target molecule. Read more...
Cloned B cell. B-cell produce antibodies. Sometimes a b-cell can be cloned, and it produces many copies of the same antibody, hence a monoclonal antibody. Monoclonal antibodies can be seen in multiple myeloma, and myoclonal gammopathy of unknown significance (mgus). Read more...

Does a monoclonal antibody reactive with the o139 antigen of e.Coli would cross react with v.Cholera o139?

Apparently not. This does not seem likely because first that the v cholera is usually found in india and bangladesh while ecoli is usually in the U.S., mexico, and south america. Second, the mechanisms are different because the genes for toxicity on the e coli strains are not present in the v cholera. Third, there seems to be no information on any cross reaction of these two o 139 strains. Read more...
Nope. The o (somatic) antigens of each gram-negative bacilli are numbered specifically for the organism. Therefore, the o139 antigen of v. Cholerae is not the same as the o139 antigen of e. Coli. Read more...