2 doctors weighed in:

Why tyramine contraindicated with mao inhibitor?

2 doctors weighed in
Dr. Michael Sinclair
Family Medicine
1 doctor agrees

In brief: Will cause severe BP

Tyramine in large doses can raise your blood pressure, that can cause a stroke and death.
Small doses don't do that because there is enough MAO in your intestinal tract to metabolize the tyramine. When you take a MAO inhibitor, tyramine is no longer metabolized in the gut, so it is free to raise your blood pressure to a very high level. This is less likely to happen with topical MAO called emsam.

In brief: Will cause severe BP

Tyramine in large doses can raise your blood pressure, that can cause a stroke and death.
Small doses don't do that because there is enough MAO in your intestinal tract to metabolize the tyramine. When you take a MAO inhibitor, tyramine is no longer metabolized in the gut, so it is free to raise your blood pressure to a very high level. This is less likely to happen with topical MAO called emsam.
Dr. Michael Sinclair
Dr. Michael Sinclair
Thank
Read more answers from doctors