Is it ok to take 150mg of ranitidine with a 500mg Tylenol (acetaminophen)?

One time? While zantac and tylenol (acetaminophen) are both liver metabolized they do not have significant interactions with each other and have decent margins of safety. BUT tylenol (acetaminophen) in large amounts (at one time) is quite toxic to the liver; and many medications have tylenol (acetaminophen) in them. So.... tylenol (acetaminophen) + Percocet + cold medicine might NOT be safe.

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