Can the pancreas be tottally removed safely?

Not really. Very rarely, such as in emergencies or specific types of pancreatic cancer. The pancreas is responsible for producing major hormones involved in sugar regulation and digestion- removal would take away all of these hormones. The pancreas is also located very close to major blood vessels and vital organs, making the surgery difficult.
Safety improved. Surgery to remove the pancreas has improved dramatically with respect to the danger of the surgery. Quoted mortality (death) due to the surgery is around 2%. There is an independent risk related to whatever disease necessitates the surgery, and there are a variety of health-related effects that come from removing the pancreas (it produces Insulin and other things). Talk with your doctors.