Many. Side effects are many and depend on the chemotherapy drugs used. Most of them are reversible and not permanent. Typical effects include fatigue, low blood counts, diarrhea, mouth sores, infection risks, nausea, vomiting, nerve damage, liver damage, skin rash. Rare side effects include strokes, blood clots, lung or heart damage, increasewd blood pressure, wound healing problems.
Adverse events (AE) Combination of chemotherapy is used in colon cancer- i.e.5fu, (fluorouracil) oxaliplatin, irinotecan, Bevacizumab etc. Each treatment will have diffferent potential ae- however in general-decrease blood counts, nausea/vomiting, numbness/tingling, diarrhea, , mucositis, constipation, fever, infection, bleeding, cold intolerance, etc-can happen. This is something you should discuss in detail with your oncologis.
It is an old regimen. It is one of the effective treatment regimens for metastatic colon Cancer which first appeared on the scene more than 5 years back and became popular for a while to be soon upgraded with other more effective modern regimens which also include Avastin (bevacizumab) in combination with chemotherapy.
It depends. ... Dysphagia is a common side effect with many chemo therapeutic regimens. Some treatments can decrease a patient's ability to fight off fungal and bacterial overgrowth in the mouth and digestive systems. The diagnosis of this isn't usually difficult and can in many cases be treated with medications.
Esophagitis. The chemo is causing slough, irritation of esophageal mucosa and spasm and difficulty swallowing most likely. Talk with oncologist for therapy.
So many variables. Too many variables to give you a pertinent answer. Consult your oncologist to help you with clinical decisions.
Standard of care. Standard of care -adjuvant chemotherapy for stage 3 colon cancer will be a combination of 5-fluorouracil and oxaliplatin or oral Capecitabine and oxaliplatin.
Effective chemo. Folfox, folfiri, xelox chemo, if elderly than using 5fu (fluorouracil) or Xeloda alone.
See an oncologist. Colon chance chemotherapy has a lot options now, and a thoughtful short and potential long term plan is what I necessary. Some oncologist believe that one day soon metastatic colon cancer may even be able to be treated as a chronic disease. I have certainly seen patients live for a decade with stage 4 disease. I wish you all the best.
What do you mean? My first question is what do you mean chemotherapy fail. What kind of symptoms the patient has to indicate failure. And to answer your question, if surgery is no longer an option to control the metastases. Then it is wait and see.
What kind of mets. It depends what kind of metastases we are talking about. If the spread to the lymph nodes, surgery and chemotherapy, and possible radiation therapy could be very helpful. If the spread to the liver the prognosis is less optimistic, unless the metastases are able to be resected. Other metastases are less promising in spite of chemotherapy and radiation therapy. Like bone and brain.
Temporary relief. The best chemo can offer metastatic colon cancer is a temporary relief of symptoms and possibly some tumor shrinkage There are no known cures from chemo due to the presence of malignant stem cells that have repairative mechanisms for damaged DNA. If the lesion is in the liver, one can attempt primary resection or microwave ablation. Shrinkage here can leade to resection and possible cure.
Relatively good. According to the Journal of Clinical Oncology XELOX is a highly effective first-line treatment for metastatic colon cancer. To be more accurate (55%) of patients achieve a response, and 30% experience disease stabilization for more than 3 months following treatment. Always consult with your oncologist.
Some effect. Single drug chemotherapy has failed to produce significant improvement in colorectal Ca. Combination chemo as in FOLFIRI with irinotecan has added about 5 month prolongation in survival and with immunotherapy using Avastin (bevacizumab) or Erbitux an additional 2-3 months can be observed. Chemo-Immuno with a mAb targeting the immunogenic protein appears to be giving further enhancement.
Better than chemo. Combining bevacizumab (BV)—a recombinant, humanized mAb targeting VEGF with irinotecan, fluorouracil (FU), and leucovorin (LV; IFL) has increased survival of patients with metastatic colorectal Ca compared with IFL It appears necessary to use combination therapy in treatment and has supported the concept that the use of immunochemotherapy improves results over chemo alone.