Vincristine ... Blockscell cycle progression. Vincristine is a vinca alkaloid originally purified from periwinkle. It binds tubulin and prevents microtubule elongation. As such, t blocks the mitotic spindle and causes mitotic arrest in dividing cells. Its primary side effects are neuropathic in nature, a reflection of the important structural role played by microtubules in neuronal projections, particularly axons.
Vinca alkaloid. It interferes with the growth of cancer cells and slows their spread in the body by binding to tubulin and inhibit microtubule formation in cancer cells and arresting cancer cell growth.