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What do my celiac disease tissue transglutaminase test results mean?

1 doctor weighed in
Dr. Charles Cattano
Internal Medicine - Gastroenterology

In brief: Depends...

If the test was performed to identify whether you have celiac disease, an unequivocally elevated ttg value is diagnostic for celiac disease.
If you are IgA deficient, and the only ttg assayed was iga, you may miss a diagnosis of celiac disease due to a falsely negative result. If you have celiac disease, ttg can be used to assess how compliant you may be with strict dietary gluten avoidance.

In brief: Depends...

If the test was performed to identify whether you have celiac disease, an unequivocally elevated ttg value is diagnostic for celiac disease.
If you are IgA deficient, and the only ttg assayed was iga, you may miss a diagnosis of celiac disease due to a falsely negative result. If you have celiac disease, ttg can be used to assess how compliant you may be with strict dietary gluten avoidance.
Dr. Charles Cattano
Dr. Charles Cattano
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