5 doctors weighed in:
Can serzone b combined with cymbalta (duloxetine)?
5 doctors weighed in

Dr. Robert Woods
Psychiatry
2 doctors agree
In brief: Theoretically
Serzone (nefazodone) is an antidepressant quite popular when introduced due to a favorable side effect profile.
Post- marketing research showed that it can cause liver failure at a rate higher than the rate in the general population. Bristol-myers squibb discontinued it, but it is still available in generic form. Combining it with Cymbalta (duloxetine) may increase risk of serotonin syndrome.

In brief: Theoretically
Serzone (nefazodone) is an antidepressant quite popular when introduced due to a favorable side effect profile.
Post- marketing research showed that it can cause liver failure at a rate higher than the rate in the general population. Bristol-myers squibb discontinued it, but it is still available in generic form. Combining it with Cymbalta (duloxetine) may increase risk of serotonin syndrome.
Dr. Robert Woods
Dr. Robert Woods
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Dr. Douglas Bey
Psychiatry
In brief: Liver toxicity
Serzone was helpful 4 some pts but taken off market because of problems with liver toxicity.

In brief: Liver toxicity
Serzone was helpful 4 some pts but taken off market because of problems with liver toxicity.
Dr. Douglas Bey
Dr. Douglas Bey
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Dr. J. Kirk Clopton
Psychiatry
In brief: Yes, but why
The mechanism of action of these two medications is similar, so i wouldn't combine them. Serzone has the benefit of having fewer sexual side effects than most of the antidepressants, but so does cymbalta (duloxetine).

In brief: Yes, but why
The mechanism of action of these two medications is similar, so i wouldn't combine them. Serzone has the benefit of having fewer sexual side effects than most of the antidepressants, but so does cymbalta (duloxetine).
Dr. J. Kirk Clopton
Dr. J. Kirk Clopton
Thank
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