5 doctors weighed in:

Can serzone b combined with cymbalta (duloxetine)?

5 doctors weighed in
Dr. Robert Woods
Psychiatry
2 doctors agree

In brief: Theoretically

Serzone (nefazodone) is an antidepressant quite popular when introduced due to a favorable side effect profile.
Post- marketing research showed that it can cause liver failure at a rate higher than the rate in the general population. Bristol-myers squibb discontinued it, but it is still available in generic form. Combining it with Cymbalta (duloxetine) may increase risk of serotonin syndrome.

In brief: Theoretically

Serzone (nefazodone) is an antidepressant quite popular when introduced due to a favorable side effect profile.
Post- marketing research showed that it can cause liver failure at a rate higher than the rate in the general population. Bristol-myers squibb discontinued it, but it is still available in generic form. Combining it with Cymbalta (duloxetine) may increase risk of serotonin syndrome.
Dr. Robert Woods
Dr. Robert Woods
Thank
Dr. Douglas Bey
Psychiatry

In brief: Liver toxicity

Serzone was helpful 4 some pts but taken off market because of problems with liver toxicity.

In brief: Liver toxicity

Serzone was helpful 4 some pts but taken off market because of problems with liver toxicity.
Dr. Douglas Bey
Dr. Douglas Bey
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Dr. J. Kirk Clopton
Psychiatry

In brief: Yes, but why

The mechanism of action of these two medications is similar, so i wouldn't combine them. Serzone has the benefit of having fewer sexual side effects than most of the antidepressants, but so does cymbalta (duloxetine).

In brief: Yes, but why

The mechanism of action of these two medications is similar, so i wouldn't combine them. Serzone has the benefit of having fewer sexual side effects than most of the antidepressants, but so does cymbalta (duloxetine).
Dr. J. Kirk Clopton
Dr. J. Kirk Clopton
Thank
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