9 doctors weighed in:
Why neostigmine is not a drug for treatment of Alzheimer's disease?
9 doctors weighed in

5 doctors agree
In brief: Doesn't get in brain
Neostigmine's chemical structure (quaternary amine) does not allow it to cross the blood brain barrier, so it does not affect cholinesterases in the brain.

In brief: Doesn't get in brain
Neostigmine's chemical structure (quaternary amine) does not allow it to cross the blood brain barrier, so it does not affect cholinesterases in the brain.
Dr. Darren Gitelman
Dr. Darren Gitelman
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Dr. Ladislav Volicer
Psychiatry - Geriatric
2 doctors agree
In brief: Would make it worse
Neostigmine is blocking effect of acetylcholine and would probably make the cognitive deficit in alzheimer§s disease worse.

In brief: Would make it worse
Neostigmine is blocking effect of acetylcholine and would probably make the cognitive deficit in alzheimer§s disease worse.
Dr. Ladislav Volicer
Dr. Ladislav Volicer
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