Are lyrica (pregabalin) and topiramate in the same family?

Yes, anticonvulsants. Topiramate (Topamax) is a newer anticonvulsant that blocks voltage-gated sodium ion channels similar to carbamazepine. Lyrica (pregabalin) is an anticonvulsant (seizure) medicine and is used off-label by many doctors as a chronic pain relief medication.