7 doctors weighed in:
Gout sufferer allergic on both allopurinol and probenecid; what's next?
7 doctors weighed in

Dr. Pierre Moeser
Internal Medicine - Rheumatology
4 doctors agree
In brief: Two options
Colchicine may control the acute attacks while other medicines are started to lower uric acid levels which will ultimately prevent gout.
One choice would be uloric which is a daily pill. If that fails, Krystexxa (pegloticase) is an an option. Krystexxa (pegloticase) is more powerful than other drugs but is given by intravenous infusion every two weeks.

In brief: Two options
Colchicine may control the acute attacks while other medicines are started to lower uric acid levels which will ultimately prevent gout.
One choice would be uloric which is a daily pill. If that fails, Krystexxa (pegloticase) is an an option. Krystexxa (pegloticase) is more powerful than other drugs but is given by intravenous infusion every two weeks.
Dr. Pierre Moeser
Dr. Pierre Moeser
Thank
Dr. Angus Worthing
Internal Medicine
1 doctor agrees
In brief: Uloric or Krystexxa (pegloticase)
Uloric works like Allopurinol and can be tolerated in many who are allergic to it.
Krystexxa, (pegloticase) an infusion, is extremely helpful at first but l may not work long term in half of patients. Ask a rheumatologist.

In brief: Uloric or Krystexxa (pegloticase)
Uloric works like Allopurinol and can be tolerated in many who are allergic to it.
Krystexxa, (pegloticase) an infusion, is extremely helpful at first but l may not work long term in half of patients. Ask a rheumatologist.
Dr. Angus Worthing
Dr. Angus Worthing
Thank
Dr. Michael Laccheo
Internal Medicine - Rheumatology
In brief: Depends
You could try uloric, although a cross reactive allergy is possible.
The next step if the gout was bad enough is pegloticase. You can also try losartan although the effect is mild (0.5 mg/dl). This also assumes you've already done all the lifestyle modifications like avoiding the wrong foods and drinks, exercise, weight loss, controlling comorbid diseases (psoriatic arthritis), etc.

In brief: Depends
You could try uloric, although a cross reactive allergy is possible.
The next step if the gout was bad enough is pegloticase. You can also try losartan although the effect is mild (0.5 mg/dl). This also assumes you've already done all the lifestyle modifications like avoiding the wrong foods and drinks, exercise, weight loss, controlling comorbid diseases (psoriatic arthritis), etc.
Dr. Michael Laccheo
Dr. Michael Laccheo
Thank
Get help from a real doctor now
Dr. Arnon Rubin
Board Certified, Internal Medicine
20 years in practice
162K people helped
Continue
108,000 doctors available
Read more answers from doctors