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Can you tell me how penicillin cause allergic reaction?

1 doctor weighed in
Dr. Thomas Josa
Internal Medicine - Allergy & Immunology

In brief: IgE antibodies

Penicillin binds to a protein in the blood and the combination is treated as an invader. Instead of creating the usual IgG antibodies the immune system mistakenly forms IgE antibodies.
The combination activates Mast cells which then release various, potent biochemical mediators that have various effects on multiple organ systems including the skin, lungs and blood vessels.

In brief: IgE antibodies

Penicillin binds to a protein in the blood and the combination is treated as an invader. Instead of creating the usual IgG antibodies the immune system mistakenly forms IgE antibodies.
The combination activates Mast cells which then release various, potent biochemical mediators that have various effects on multiple organ systems including the skin, lungs and blood vessels.
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