4 doctors weighed in:
Can long term use of methylphenidate in adults cause depression as a side effect? Would antidepressants help with that?
4 doctors weighed in

Dr. J. Kirk Clopton
Psychiatry
1 doctor agrees
In brief: No evidence
There is no published data showing a link between the two.
Antidepressants can be very helpful.

In brief: No evidence
There is no published data showing a link between the two.
Antidepressants can be very helpful.
Dr. J. Kirk Clopton
Dr. J. Kirk Clopton
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1 comment
Dr. Neil Liebowitz
While depression can be a separate problem, it is not uncommon for depression to occur in people abusing stimulants. Stimulants make poor antidepressants because of tolerance. Some people with ADD sx many really have a mood disorder or sleep apnea, in which case the Ritalin would not help and may make things worse
Dr. Edward Smith
Neurology
1 doctor agrees
In brief: Apathy mainly
Methamphetamine causes depletion of Dopamine from the brain more than other neurotransmitters.
Low Dopamine is associated with apathy which can resemble depression. Low serotonin is the major underlying cause of depression. Low norepinephrine is a cause for fatigue. All these neurotransmitters are affected by "meth" but the main one is dopamine. Most anti-depressants don't target dopamine.

In brief: Apathy mainly
Methamphetamine causes depletion of Dopamine from the brain more than other neurotransmitters.
Low Dopamine is associated with apathy which can resemble depression. Low serotonin is the major underlying cause of depression. Low norepinephrine is a cause for fatigue. All these neurotransmitters are affected by "meth" but the main one is dopamine. Most anti-depressants don't target dopamine.
Dr. Edward Smith
Dr. Edward Smith
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