How can I get rid of lines near side of mouth/ lips?

See a dermatologist. For some people, topical prescription medicines (retinoids) can be helpful in reducing fine lines. For deeper lines, fillers can be injected to erase them or make them shallower. For lines caused by muscle contraction, botox can be helpful, though most mouth/lip lines are treated topically or with fillers. No oral supplements, exercises, or home devices have been shown to work well for this.