4 doctors weighed in:
Can an anti-epileptic drug such as keppra (levetiracetam) prevent seizures that happen from taking tramadol?
4 doctors weighed in

Dr. James Wolfe
Pain Management
3 doctors agree
In brief: Perhaps.
In theory, the answer is yes.
However, the vast majority of patients who do not already have a seizure disorder will never have seizures or seizure-like activity if they remain below 300mg/day of tramadol. If seizure-like activity is noted, the better choice is to eliminate tramadol, rather than minimize side effects with yet another medication.

In brief: Perhaps.
In theory, the answer is yes.
However, the vast majority of patients who do not already have a seizure disorder will never have seizures or seizure-like activity if they remain below 300mg/day of tramadol. If seizure-like activity is noted, the better choice is to eliminate tramadol, rather than minimize side effects with yet another medication.
Dr. James Wolfe
Dr. James Wolfe
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