7 doctors weighed in:
Why does elavil or amitriptyline make you gain weight?
7 doctors weighed in

Dr. Chris Esguerra
Psychiatry
4 doctors agree
In brief: Antihistamine
The antihistamine effect of Amitriptyline is what stimulates appetite and ultimately leads to weight gain (also causes sleepiness).
This class of tricyclic antidepressants (called tertiary amines) tends to have stronger antihistamine effect. The secondary amines like nortriptyline and desiprimine have less of the antihistamine effect.

In brief: Antihistamine
The antihistamine effect of Amitriptyline is what stimulates appetite and ultimately leads to weight gain (also causes sleepiness).
This class of tricyclic antidepressants (called tertiary amines) tends to have stronger antihistamine effect. The secondary amines like nortriptyline and desiprimine have less of the antihistamine effect.
Dr. Chris Esguerra
Dr. Chris Esguerra
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Dr. Mark Reynolds
Psychiatry
3 doctors agree
In brief: Histamine
Likely related to h1 histamine blockade, some to Alpha adrenergic effects.

In brief: Histamine
Likely related to h1 histamine blockade, some to Alpha adrenergic effects.
Dr. Mark Reynolds
Dr. Mark Reynolds
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Dr. Alan Ali
Psychiatry
In brief: Elavil (amitriptyline)
Strong anticholinergic effects.

In brief: Elavil (amitriptyline)
Strong anticholinergic effects.
Dr. Alan Ali
Dr. Alan Ali
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Dr. Byron Law-Yone
Psychiatry
In brief: Not sure, but ---
Med can change metabolism or appetite.
When we feel better we eat moe. When we dont feel well we often eat more too.. So these comfort easing eating behaviors create obese societies. There are complex brain centers that control are eating and these meds maybe working at these areas also

In brief: Not sure, but ---
Med can change metabolism or appetite.
When we feel better we eat moe. When we dont feel well we often eat more too.. So these comfort easing eating behaviors create obese societies. There are complex brain centers that control are eating and these meds maybe working at these areas also
Dr. Byron Law-Yone
Dr. Byron Law-Yone
Thank
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