What is cause of cramps? Ibuprofen
may make BP harder to control.
It should be taken occasionally, but not on a regular basis (more than once/twice daily for a few days at a time) .
I do not believe Ibuprofen specifically reacts or causes adverse reaction with diltiazem, but it may make BP harder to control by decreasing kidney function (and thus body's ability to get rid of salt/sodium).